منابع مشابه
How IRE1 Reacts to ER Stress
The long-awaited structure of the effector portion of IRE1, the endoplasmic reticulum stress transducer, is published in this issue of Cell (Lee et al., 2008). This structure provides new insight into the mysterious coupling of kinase and endoribonuclease activities in the oldest, most-conserved branch of the unfolded protein response in eukaryotes.
متن کاملHow We Know Our Senses
I propose a new criterion by which, I hold, subjects recognize and distinguish their sensory modalities. I argue that, rather than appealing to one of the standard criteria (sense organ, proximal stimulus, phenomenal character, or representational content (Grice 1962, Macpherson 2011a)) or to O’Dea’s (2011) proprioceptive content, we need to introduce the criterion of location in the functional...
متن کاملIRE1: ER stress sensor and cell fate executor.
Cells operate a signaling network termed the unfolded protein response (UPR) to monitor protein-folding capacity in the endoplasmic reticulum (ER). Inositol-requiring enzyme 1 (IRE1) is an ER transmembrane sensor that activates the UPR to maintain the ER and cellular function. Although mammalian IRE1 promotes cell survival, it can initiate apoptosis via decay of antiapoptotic miRNAs. Convergent...
متن کاملTwo regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins
Chaperone protein BiP binds to Ire1 and dissociates in response to endoplasmic reticulum (ER) stress. However, it remains unclear how the signal transducer Ire1 senses ER stress and is subsequently activated. The crystal structure of the core stress-sensing region (CSSR) of yeast Ire1 luminal domain led to the controversial suggestion that the molecule can bind to unfolded proteins. We demonstr...
متن کاملEmpiricism Without the Senses: How the Instrument Replaced the Eye
Abstract The optical instruments developed through the seventeenth century allowed peering into the very far and the very small; a spectacle never before experienced. The telescope, and later the microscope, was now expected to answer fundamental questions and resolve cosmological riddles by direct observation into the foundations of nature. But this ability came at an unexpected price and with...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2007
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1791iti5